Diabetic nephropathy (DN) has been identified as the major cause of end-stage renal disease (ESRD) in most developed countries.MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F transcription factor 3 (E2F3) could facilitate podocyte injury.Nevertheless, whether E2F3 is involved in
Abstract Identifying effective drug targets, with little or no side effects, remains an ever challenging task.A potential pitfall of failing to uncover the correct drug targets, due to side effect of pleiotropic genes, might lead the potential drugs to be illicit and withdrawn.Simplifying disease complexity, for the investigation of the mechanistic
Use of umbilical unrelated cord-blood (UCB) cells as an alternative source of hematopoietic cell transplantation has been widely used mainly for patients lacking an HLA-matched donor.UCB present many advantages over bone marrow or mobilized peripheral blood from volunteer donors, such as rapid availability, absence of risk for the donor, and decrea
Air traffic affects cloudiness, and thus climate, by emitting exhaust gases and particles.The study of the evolution of contrail properties is very challenging due to the complex interplay of vortex dynamics and the atmospheric environment (e.g.temperature, supersaturation).Despite substantial progress in recent years, the optical, microphysical, a
Abstract This study focuses on hippocampal and amygdala volume, seed-based connectivity, and psychological traits of Holocaust survivors who experienced stress during prenatal and early postnatal development.We investigated people who lived in Central Europe during the Holocaust and who, as Jews, were in imminent danger.The group who experienced q6